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Water On The Brain: A Biobank Of Failed Shunt Devices

Hydrocephalus, otherwise known as water on the brain, is a condition where cerebrospinal fluid (CSF) accumulates within the brain. Hydrocephalus that occurs in childhood has a frequency of about 1 person in 1100 within the USA. The surgical placement...

Leptin Associated With Cognitive Impairment In Older Adults Scheduled For Surgery

Adipokines are cytokines secreted by adipose (fat) tissue. Their existence was first noted in 1994, with the discovery of leptin. This cytokine is known to suppress hunger, but also promotes atherosclerosis, endothelial dysfunction and inflammation. Another adipokine, adiponectin is...

An Organoid Model Of The Human Midbrain

In Parkinson’s disease dopaminergic neurons are irrecoverably lost from the midbrain resulting in slowed movement, tremors and other symptoms. Dopamine augmentation is the main treatment for Parkinson’s, however, there is no cure available that can reverse the symptoms, partly...

Phenotypic Factors Including Brain Morphology Associated With Epilepsy In The UK Biobank

Epileptic seizures are episodes that can vary from brief, nearly undetectable, periods to long periods of vigorous shaking, which can result in injury in addition to the effect of the seizure on the brain. According to the World Health...

UK Biobank Cognitive Tests – Are They Valid And Reliable?

Most participants in the UK biobank underwent web-based cognitive testing when they enrolled. The baseline test was only five minutes, consisting of Pairs Memory test, a test of visual memory, and the Reaction Time test. A subset underwent tests...

Deriving Brain Age From Imaging In The UK Biobank

Magnetic resonance imaging (MRI) can be used to obtain a measure of “brain age”, which may be different from chronological age. This is achieved by comparing an individual's brain scan with a population-wide dataset. The “brain age gap” (or...

Air Pollution And Thalamic Volume In The UK Biobank

The thalamus is a large “chamber” connected to the spinal cord, located in the forebrain. It is connected to the cerebral cortex via nerve fibres facilitating cross-talk. Functions of the thalamus include the regulation of consciousness, sleep, and alertness. Air...

Allen Institute Releases High-Resolution Dataset Of The Wiring Of The Mouse Brain

In their quest to map the millions of neural highways and connections in the brain, researchers at the Allen Institute have made a significant step forward, unveiling a new high-resolution view of the wiring diagram of the mouse brain....

New Papers Discuss The Science And Ethics Of Human Brain Organoids

Research involving the transplantation of human “mini-brains”—known as brain organoids—into animals to study disease can provide crucial insight’s into disease. Medical ethicist’s have raised a concern that must be considered. There is the possibility, however minute, that the grafted...

A:Head Bio AG Incorporated To Use Cerebral Organoids For CNS Drug Discovery

a:head bio AG, an Austrian biotech company focused on the development of next generation therapeutics for the treatment of brain disorders based on human cerebral organoids has recently been incorporated. The new venture is based on groundbreaking technology developed at the Institute...

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