A Biobank Cost Model: Shanghai Birth Cohort Study
The infrastructure required for biobanking is costly and often depends on government funds to some extent. Resources for establishing cost are available, such as the biospecimen user fee calculator tool developed by the Canadian Tissue Repository Network...
Coronary Artery Disease Genetic Risk Score: Is It Clinically Useful In Over 45s?
Genomic risk prediction based on polygenic risk scores generated
from genome-wide association studies (GWAS) to summarize the contribution of
anywhere between hundreds to millions of genetic variants to determine the risk
of developing multifactorial diseases such as coronary artery disease...
Observations On Recruitment For The Mayo Clinic Biobank
In order to draw generalizable conclusions, it is important
that cohort studies represent the population of interest faithfully. Against
this backdrop it has been noted that not all individuals are equally willing to
participate in biobank related studies. Factors associated...
CLOVER Study Of PDL1 In NSCLC Demonstrates PCR RNA Expression Analysis Not Equivalent To...
Programmed cell death ligand 1 (PDL1) is approved therapeutic target in lung cancer patients. PDL1 expression above a set threshold must be confirmed by companion immunohistochemistry (IHC) test in order for the patient to be eligible for...
Telomere Length, Pathways, And Disease Associations
Telomeres are structural DNA elements of repetitive
nucleotide sequences complexed with proteins at the ends of each chromosome.
They preserve chromosome stability, but also determine the replicative limits of
a given cell. That is telomere length decreases with each cell...
Pre-Emptive Pharmacogenomics At The Colorado Center for Personalized Medicine Biobank
Pharmacogenomics can be described as the scientific process
of selecting a therapeutic regimen for a patient with a given condition that
takes account of patient specific responses and drug side effects using gene
panels and single nucleotide polymorphism (SNP) data...
White Paper – Using a LIMS to Improve Laboratory Efficiency and Profitability
Autoscribe Informatics has published a new white paper entitled: "Using a LIMS to Improve Laboratory Efficiency and Profitability". This comprehensive document can be downloaded at: https://www.autoscribeinformatics.com/resources/using-a-lims-to-improve-laboratory-efficiency-and-profitability. It highlights the extensive capabilities that a LIMS (Laboratory Information Management System) can provide...
Cigarette Associated Cardiovascular Disease And Inflammation In The Guangzhou Biobank
Cigarette smoking is the leading preventable cause of death
(one in five deaths) in the United States. It is also highly prevalent in
China, and globally. Sadly, 90% of all lung cancer deaths can be attributed to
smoking. It also...
Biobank Investigation Of Gut Methanogens In Kidney Transplant Recipients
Kidney transplant is a common procedure in those with
late-stage renal disease. These patients can experience gastrointestinal
complaints such as diarrhea, which may be associated with premature kidney
allograft failure and mortality. Historically, has been thought due to
medication, however the...
Genetically Predicted Iron Status Correlated With Risk Of Liver Cancer
Iron overload is a known risk factor for liver disease including liver cancer. The potential for iron overload to be a risk factor in other cancers was poorly understood. Susanna C. Larsson of the...
