Collagen Content Changes Detected By Raman Spectroscopy In Herniated Spinal Chord
In the spinal cord, the nucleus pulposus (NP) is the collagen rich core of the intervertebral discs. Intervertebral disc degeneration (IDD) is thought to be a major contributor to lower back pain, which the majority of people...
Serum Uric Acid Predicts Kidney Cancer Incidence
According to the US Surveillance, Epidemiology, and End Results program, the outlook for kidney cancer patients is generally favourable with an overall five year survival rate of 77%, furthermore the survival rate in the 65-74 age category...
PALB2 May Be A Risk Locus For Ovarian Cancer
According to US Surveillance, Epidemiology, and End Results (SEER), overall, the five year survival rate for ovarian cancer is 49%, however for those aged 15-39 the survival rate is 81% and declines steadily with age; 65-74 year...
Estrogen Receptor Isoforms Are Down-Regulated In Hepatocellular Carcinoma
Estrogen receptor alpha (ERα) translocates to the nucleus and induces gene expression upon activation. The estrogen receptor is a target of US Food and Drug Administration FDA approved drugs such as the selective estrogen receptor degrader called...
Apolipoprotein E (APOE) Isoform Association With Aging In UK Biobank
The APOE (Apolipoprotein E) gene has three main isoforms known as APOE2, APOE3, and APOE4. The ε4 allele is thought to be the oldest, whereas ε2 is the most recently evolved. In the European ancestry population the...
Complement And Coagulation Disorders Associated With COVID-19
Recent structure based comparisons suggest that coronavirus proteins mimic at least 140 human proteins, including those in the complement and coagulation pathways. The complement cascade leading to cell death and inflammation is part of the innate immune...
Genetics Of Susceptibility To Viral Infection
The severity of infectious diseases vary from person to person partly due to individual genetic factors. This can shape genetics at the population level, for example inherited sickle cell disease can protect against malarial infection, and is...
Markers Of “Immune Hot” Esophageal Adenocarcinoma
According to the US National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results Program (SEER), the incidence of adenocarcinoma of the esophagus (EAC) is greatest in Caucasians, but is also prevalent in other ethnicities and mainly affects...
COVID-19 Risk In Different Ethnic And Socioeconomic Groups Within UK Biobank
Socioeconomic and ethnic factors may influence the risk of viral infection. For example, both economic circumstances and cultural influences may impact the extent to which people can implement distancing measures, thus modifying their risk. The extent to...
A Standardized Mega-Biobank Phenomic Library From The Million Veteran Program
Often International Classification of Diseases (ICD) codes are used as a proxy for clinical phenotypes, however their intended purpose is for billing, determining treatment, and statistics collection and therefore may not always be the best representation of...
