Measures Of Air Pollution And Associations With Biobank Data

Air pollution may influence brain volume. Total grey matter to white matter volumes are thought to be related to cognitive function or decline. Air pollution might affect total gray-matter and white-matter volumes which could be important in determining individual and...

Study: Diet And Mortality In The UK Biobank

Dietary recommendations to the general public can be unclear. They often don’t take into account nutrient and or drug interactions. For example, the long-held view that saturated fat should be reduced has been challenged by recent studies suggesting that saturated...

Diabetes, Dyslipidemia and Hypertension In The Taiwan Biobank

Diabetes, dyslipidemia and hypertension have global prevalence rates of 8.5%, 38%, and 40%, respectively. Disease prevalence may be used as a proxy for disease incidence so it follows that population clusters with reduced disease prevalence may potentially represent individuals with...

Investigation Of IL-22 Polymorphisms And Malaria In Saudi Arabia

The World Health Organization (WHO) has estimated that there were 435,000 malaria related deaths in 2017. The disease is a long-standing global health threat that currently affects more than 219 million people in a total of 100 nations. The unicellular...

A Biobank Cost Model: Shanghai Birth Cohort Study

The infrastructure required for biobanking is costly and often depends on government funds to some extent. Resources for establishing cost are available, such as the biospecimen user fee calculator tool developed by the Canadian Tissue Repository Network...

Coronary Artery Disease Genetic Risk Score: Is It Clinically Useful In Over 45s?

Genomic risk prediction based on polygenic risk scores generated from genome-wide association studies (GWAS) to summarize the contribution of anywhere between hundreds to millions of genetic variants to determine the risk of developing multifactorial diseases such as coronary artery disease...
ISBER Best Practices Recommendations for Biobanks

ISBER Best Practices Recommendations for Biobanks and Biorepositories

Does Your Biorepository Follow ISBER Best Practices Recommendations? Biorepositories provide essential support to biomedical researchers by collecting, processing, storing and distributing millions of biospecimens every year. Biorepository staff must navigate complex international regulatory rules governing the use of biospecimens and...

Observations On Recruitment For The Mayo Clinic Biobank

In order to draw generalizable conclusions, it is important that cohort studies represent the population of interest faithfully. Against this backdrop it has been noted that not all individuals are equally willing to participate in biobank related studies. Factors associated...

CLOVER Study Of PDL1 In NSCLC Demonstrates PCR RNA Expression Analysis Not Equivalent To...

Programmed cell death ligand 1 (PDL1) is approved therapeutic target in lung cancer patients. PDL1 expression above a set threshold must be confirmed by companion immunohistochemistry (IHC) test in order for the patient to be eligible for...

Telomere Length, Pathways, And Disease Associations

Telomeres are structural DNA elements of repetitive nucleotide sequences complexed with proteins at the ends of each chromosome. They preserve chromosome stability, but also determine the replicative limits of a given cell. That is telomere length decreases with each cell...

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