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Iron Loading Reduced Insulin Secretion By Pancreatic Beta-Cell Lines

Longitudinal analyses of iron-overloaded individuals have indicated that patients in the highest quartile of serum ferritin levels, a proxy for iron, have 3.5-fold greater risk of developing Type II Diabetes over a 6-year period. The exact mechanism...

Age-Of-Onset Genome-Wide Association Studies In Allergic Disease

Susceptibility to allergic diseases can be predicted by genome-wide association studies (GWAS) based on biobanks of sequenced DNA from people with said diseases. Knowing the likely age-of-onset of these diseases would be helpful for risk management and...

Lack Of African Biobank Data Results In Iron Deficiency Anaemia Remaining Unexplained

Iron is a dietary requirement, women aged 19-50 needing the most, routinely around 18mg/day, moreover all adults need at least 8mg/day. Pregnant women need even more. Dietary sources include, but are not limited to, meats, nuts, grains...

Predicting Risk Of Fracture Using Polygenic Risk Score Of Speed Of Sound Through Bone

As we age, the risk of bone fracture increases. Doctors developed the Fracture Risk Assessment Tool (FRAX), which takes account of age, weight, gender, smoking history, alcohol use and family history of fracture, as an initial approach...

Biomarker Candidates For Dementia With Lewy Bodies Identified In Cerebrospinal Fluid

Besides Alzheimer’s disease (AD), Dementia with Lewy Bodies (DLB) is the second most common form of progressive dementia, accounting for up to 20% of cases. The main protein component of Lewy Bodies, which form in the nerve...

Multiplex Method For Detection Of Pathogenic Pig Coronaviruses

Pathogenic pig coronaviruses found in the intestine (enteric) produce similar symptoms, namely diarrhea with a reduced ability to digest food leading to dehydration and starvation. Transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine deltacoronavirus...

Lessons Learned From Participation In The 100,000 Genomes Project

The 100,000 Genomes Project (100KGP) was established to sequence genomes from people including around 85,000 UK National Health Service (NHS) patients affected by a rare disease, or cancer. Announced in 2012, the main aims were to:

Learning From Human Bile – A Machine Intelligence Approach

The digestive fluid called bile is made up of acids, salts, fats, and the pigment bilirubin, stored and concentrated in the gall bladder, and produced by the liver. Protein is a significant component of bile, 5% of...

An Organoid Model Of The Human Midbrain

In Parkinson’s disease dopaminergic neurons are irrecoverably lost from the midbrain resulting in slowed movement, tremors and other symptoms. Dopamine augmentation is the main treatment for Parkinson’s, however, there is no cure available that can reverse the...

Collagen Content Changes Detected By Raman Spectroscopy In Herniated Spinal Chord

In the spinal cord, the nucleus pulposus (NP) is the collagen rich core of the intervertebral discs. Intervertebral disc degeneration (IDD) is thought to be a major contributor to lower back pain, which the majority of people...

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