Biospecimen Quality in Clinical Research

Abstract Biospecimens form an integral part of many clinical research studies. The production of valid clinical data sets depends largely upon the quality of biospecimens utilized in the study. Annotations of biospecimens help unveil information related to disease prognosis, diagnosis,...

Biobanking Science: Storing Cells at Room Temperature

Cryopreservation is the gold standard method to store biospecimens in biobanking organizations. Cryopreservation usually involves flash freezing samples and storing them at ultra-low temperatures (-160°C to -190°C) to prevent chemical degradation. If biobanking scientists follow strict freezing...
Biobanked plasma samples had stable IL6 and CRP levels

Biobanking Science: How Storage Affects Inflammatory Biomarkers

Biobanking storage conditions can affect long-term sample quality and integrity1. A number of biomarkers are particularly sensitive to storage temperature and can degrade even when biobanked at -80°C. Furthermore, researchers often struggle with variable results from assays run in...
ultra-fast vitrification

Biobanking Science: High-Speed Freezing Protects Tumor Cell Quality

Biobanks around the world store many different types of biological samples. Circulating tumor cells (CTCs) are commonly stored in biobanks as these cells can be used to diagnose cancer in patients and to monitor disease progression. CTCs break off...

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