Technology in Precision Medicine

The field of medicine is ever evolving, with new techniques and treatments being developed for a range of conditions across the spectrum. The way we understand medicine, fields such as diagnostics and treatments, is also changing. Instead of a ‘one...

Telomere Length, Pathways, And Disease Associations

Telomeres are structural DNA elements of repetitive nucleotide sequences complexed with proteins at the ends of each chromosome. They preserve chromosome stability, but also determine the replicative limits of a given cell. That is telomere length decreases with each cell...

Pre-Emptive Pharmacogenomics At The Colorado Center for Personalized Medicine Biobank

Pharmacogenomics can be described as the scientific process of selecting a therapeutic regimen for a patient with a given condition that takes account of patient specific responses and drug side effects using gene panels and single nucleotide polymorphism (SNP) data...

Biobank Investigation Of Gut Methanogens In Kidney Transplant Recipients

Kidney transplant is a common procedure in those with late-stage renal disease. These patients can experience gastrointestinal complaints such as diarrhea, which may be associated with premature kidney allograft failure and mortality. Historically, has been thought due to medication, however the...

Study Of Antibiotic Resistance In A Bacterium Responsible For A Third Of All Gram-Negative...

According to the Centers for Disease Control and Prevention and the Infectious Disease Society of America, each year in the USA alone, at least 2 million people are infected with bacteria that are resistant to antibiotics and more than 100,000...

Application Of Liquid Biopsy NGS In Non-Squamous Cell Lung Carcinoma Patient Treatment Decisions

Lung cancer is the leading cause of cancer related death. Squamous-cell carcinoma, a type of non-small-cell lung carcinoma (NSCLC), comprises 25–30% of all lung cancer cases and is strongly correlated with cigarette smoking. The remaining 70-75% of lung cancer cases...

A Systems Approach To Cerebrospinal Fluid Analysis

Found in the brain and spinal cord, the cerebrospinal fluid (CSF) is a clear, colorless fluid with a total volume of about 125ml per person, produced by specialized neuroglia called ependymal cells, that acts as a buffer and cushioning solution....

Genetic Predisposition To Atherosclerosis A Risk Factor For Coronary Heart Disease In Type II...

According to the US Centers for Disease Control and Prevention (CDC) 1 in 10 Americans has diabetes. The global prevalence is similar with at least 422 million living with diabetes according to the World Health Organization (WHO). There are two...

A Living Biobank Of Non-Small Cell Lung Cancer Organoids

Globally, cancer of the lung is the most common cause of cancer related mortality. It is also the most commonly diagnosed. 3D patient derived organoids provide a more faithful model of cancer than 2D in vitro cell culture and represent...

Biobank Study Reveals New Gene Variants Implicated In Asthma

Asthma is a chronic condition that can sporadically effect breathing. People with the condition have narrowed inflamed airways, which produce excess mucus, restricting breathing. The “Dutch” hypothesis suggests that asthma may develop into COPD. According to the US Centers for...

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