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Biopreservation Science

Liquid nitrogen free sperm biobanking

Biobanking Science: Biobank Sperm Without Liquid Nitrogen

With gene editing technology such as CRISPR, it is becoming quicker and easier to generate disease models for medical research. Researchers around the world use tens of thousands of different mouse lines. Research institutions can save money and reduce...
Lab-grown liver organoids

Biobanking Science: Growing Liver Organoids From Tumor Biopsies

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and causes over 700,000 deaths each year (1). The number of HCC cases has dramatically risen over the past two decades due to an increase in infectious hepatitis,...
ISBER Best Practices Recommendations for Biobanks

ISBER Best Practices Recommendations for Biobanks and Biorepositories

Does Your Biorepository Follow ISBER Best Practices Recommendations? Biorepositories provide essential support to biomedical researchers by collecting, processing, storing and distributing millions of biospecimens every year. Biorepository staff must navigate complex international regulatory rules governing the use of biospecimens and...
Embalming can preserve large biospecimens.

Biobanking Science: Preserving Large Biospecimens

Biobanks store many different types of biospecimens, ranging from cells and small tissue samples right through to whole organs, whole limbs or even whole bodies. Cells and small biospecimens can be flash frozen in cryoprotectant solutions and stored in...
Biobanking professionals should be aware of leached compounds from plastic consumables.

Biobanking Science: Plastic Tubes Can Contaminate Biobanked Samples

Plastics Can Cause Experimental Errors in Biobanks Biobanks and laboratories use an array of plastic consumables such as pipette tips, sample storage tubes and cell culture flasks. Plastic consumables are convenient, cost-effective and can be sterile, DNase and RNase free....
Biobanks store blood products.

Biobanking Science: Maximizing Red Blood Cell Life in Biobanks

Blood transfusions are a common part of modern medicine and have been used to save human patients for 200 years. Biobanks play an integral part in this process by collecting and storing units of blood from blood donors. According...

Biobanking Science: Storing Cells at Room Temperature

Cryopreservation is the gold standard method to store biospecimens in biobanking organizations. Cryopreservation usually involves flash freezing samples and storing them at ultra-low temperatures (-160°C to -190°C) to prevent chemical degradation. If biobanking scientists follow strict freezing and thawing...
Biobanks can isolate macromolecules from paraffin-embedded tissues.

Biobanking Science: Mining Paraffin-Embedded Samples for DNA, RNA and Protein

Biobanks may choose to store biological samples as formalin-fixed paraffin-embedded (FFPE) blocks. FFPE preservation is the standard method of collecting and storing surgical pathology samples. This biobanking method preserves tissue morphology at room temperature for many years and is...

New Technology Allowing Room Temperature Storage Of A Vaccine, Developed At University Of Bath

Scientists working on a new tuberculosis (TB) vaccine have achieved a major step forward by showing that a promising TB antigen and a novel vaccine adjuvant can be protected from heat damage with a technique, “ensilication”, developed at the...

Sample Processing Has Important Consequences For Single Cell Sequencing Studies

Single-cell transcriptomics is a relatively new technology that reads and reports the gene expression profile of individual cells by simultaneously measuring the mRNA concentration of all the cell’s genes. This is achieved through microfluidic chip single cell isolation, barcoding, cDNA amplification and sequencing....

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