First Healthy Aging Data Release From 2570 Participants In The Medical Genome Reference Bank

The Medical Genome Reference Bank (MGRB) is planned to contain the whole genome sequences (WGS) of over 4000 elderly individuals with no reported history of cancer, cardiovascular disease, or neurodegenerative diseases until at least age 70.

Biobank Study Reveals New Gene Variants Implicated In Asthma

Asthma is a chronic condition that can sporadically effect breathing. People with the condition have narrowed inflamed airways, which produce excess mucus, restricting breathing. The “Dutch” hypothesis suggests that asthma may develop into COPD. According to the US Centers for...

Potential Targets For Opioid Addiction Treatment Uncovered By GWAS

The USA is in the midst of an opioid addiction crisis with overdoses having killed 47,600 people in 2017, according to the Centers for Disease Control and Prevention (CDC). Opioids such as OxyContin® and Vicodin® are used in pain medications...

Multinational Kids-DOTT Trial Of Anticoagulant Therapy For Venous Thromboembolism

Enrollment has completed for a landmark randomized clinical trial at Johns Hopkins All Children’s on the duration of anti-clotting medication (anticoagulant) therapy for venous thromboembolism (VTE) in patients under 21 years old — the Kids-DOTT trial. A multinational biobank of...

Age And Long-Term Conditions Are Linked To Accelerated Loss Of Skeletal Muscle

A new study led by the AGE Research Group, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, UK, describes the prevalence of sarcopenia in the UK Biobank, a large sample of men and women aged 40–70...

The Consortium On Vulnerability To Externalizing Disorders And Addictions – cVEDA

The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA) is a proposed multi-site, international, collaborative, cohort study based in India. It aims to examine the interactions of environmental exposures, and genomic influences on neurodevelopmental trajectories and...

Broad And Sanger Reproduce CRISPR-Cas9 Genetic Knock-Out Screens In 725 Cancer Cell Line Models

A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models across 25 different cancer types. Scientists at the Wellcome Sanger Institute and the...

Ambry Genetics Show Testing RNA And DNA Together Is More Sensitive For Breast Cancer...

Researchers at Ambry Genetics, a leading clinical genetic testing lab, have announced new data showing that conducting RNA and DNA tests for hereditary cancer risk at the same time identifies more patients with mutations that increase cancer risk than DNA...

Biobanking Teeth Could Help To Forecast Mental Health Problems

Teeth could serve as an actionable new tool capable of measuring the presence and timing of childhood adversity, a major risk factor for psychiatric and physical health concerns in the future. The novel approach is outlined in...

New Acoustofluidic Saliva Exosome Liquid Biopsy For Human Papilloma Virus 16

Unfortunately, cancers that occur in the back of the mouth and upper throat are often not diagnosed until they become advanced, partly because their location makes them difficult to see during routine clinical exams. A report in...

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