Cigarette Associated Cardiovascular Disease And Inflammation In The Guangzhou Biobank

Cigarette smoking is the leading preventable cause of death (one in five deaths) in the United States. It is also highly prevalent in China, and globally. Sadly, 90% of all lung cancer deaths can be attributed to smoking. It also causes 80%...

Genetically Predicted Iron Status Correlated With Risk Of Liver Cancer

Iron overload is a known risk factor for liver disease including liver cancer. The potential for iron overload to be a risk factor in other cancers was poorly understood. Susanna C. Larsson of the Karolinska Institutet, Stockholm, Sweden, and colleagues...

Impact Of Diet And Exercise On “Good Cholesterol” Levels In A Taiwanese Population

“Good cholesterol”, the common name for high-density lipoprotein (HDL) complex, has a mean size of 8–10 nm and a density of 1.063–1.21 g/ml. The HDL particle consists of a central core of esterified cholesterol with a surrounding monolayer of phospholipids, free cholesterol,...

Biobank Study Of Severe Deficiency Of Vitamin D In Pulmonary Arterial Hypertension Patients

Vitamin D is produced in the skin by photochemical transformation of 7-dehydrocholesterol (7DHC) into pre-vitamin D and can also be absorbed from dietary intake. In blood 25 hydroxyvitamin D (25(OH)D) is the most abundant and studied form of vitamin D and provides...

A New Blood Test Algorithm mPoA – Quantifying Biological Aging

People age at different rates determined by both their environment/ lifestyle and genetics. Biological aging is the gradual and progressive decline in body integrity that occurs over time eventually leading to loss of vitality or illness/ disability in some cases. Measures of...

Study Highlights Nutritional Biomarkers In Dementia

According to the World Health Organization (WHO), the global number of people living with dementia is set to triple to 150 million by 2050. The condition which involves cognitive decline and eventual death can affect people in ways they cannot perceive and...

First Healthy Aging Data Release From 2570 Participants In The Medical Genome Reference Bank

The Medical Genome Reference Bank (MGRB) is planned to contain the whole genome sequences (WGS) of over 4000 elderly individuals with no reported history of cancer, cardiovascular disease, or neurodegenerative diseases until at least age 70. The study design,...

Biobank Study Reveals New Gene Variants Implicated In Asthma

Asthma is a chronic condition that can sporadically effect breathing. People with the condition have narrowed inflamed airways, which produce excess mucus, restricting breathing. The “Dutch” hypothesis suggests that asthma may develop into COPD. According to the US Centers for Disease Control and...

Potential Targets For Opioid Addiction Treatment Uncovered By GWAS

The USA is in the midst of an opioid addiction crisis with overdoses having killed 47,600 people in 2017, according to the Centers for Disease Control and Prevention (CDC). Opioids such as OxyContin® and Vicodin® are used in pain medications and many...

Multinational Kids-DOTT Trial Of Anticoagulant Therapy For Venous Thromboembolism

Enrollment has completed for a landmark randomized clinical trial at Johns Hopkins All Children’s on the duration of anti-clotting medication (anticoagulant) therapy for venous thromboembolism (VTE) in patients under 21 years old — the Kids-DOTT trial. A multinational biobank of blood samples for...

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