Tag: heart disease
Stem Cell Banking: Current Trends, Benefits, Emerging Issues and Challenges
Recent scientific advancements have made stem cell therapy an emerging and promising area of research. The establishment of stem cell banks around the globe has been growing rapidly, aimed at preserving the characteristics of the cells, preventing contamination, and...
Recapitulating Pharmacology With Genetics
The medical term for heart rate over 100 beats per minute is tachycardia. The small molecule ivabradine reduces heart rate via specific inhibition of the pacemaker current. It is also used to alleviate chest pain (angina pectoris) and as...
Some Brugada Syndrome Patients At Risk Of Sudden Cardiac Death Have GSTM3 Deletion
Brugada syndrome (BrS) is a disorder of the heart rhythm that can result in sudden cardiac death, which may be triggered by circumstances, and has a genetic basis. Faster, abnormal rhythm may be triggered by electrolyte imbalances, certain drugs,...
Therapeutic Avenue For Acute Coronary Syndrome? – Exploring The Circular RNA Profile
Circular RNAs (circRNA) result from pre-mRNA back-splicing. Next generation sequencing has a blind spot for these circRNAs due to their lack of polyA tails and thus their abundance has only recently been appreciated. Using appropriate primers and/or RNase A...
Making Associations With Dilated Cardiomyopathy Using MRI
Under the condition of dilated cardiomyopathy (DCM), the heart becomes enlarged and cannot pump blood effectively, which can proceed to heart failure. It is the most common reason for heart transplantation. There are both extrinsic and genetic factors that...
Kidney Injury After Heart Surgery – A Japan National Center Biobank Network Investigation
Sudden injury to the kidneys or acute kidney injury (AKI) in which waste excretion into urine is impaired can occur as a result of a multitude of shocks to the body including sepsis and cardiac surgery. The presence of...
Understanding Titin Gene Mutation In Heart Disease; Penn Medicine And Geisinger Close In
In a new study published in the journal Circulation, researchers from Penn Medicine and Geisinger reviewed TTN (titin) gene sequences of more than 70,000 people, and found that 95 percent of patients who had the genetic mutations did not...
Biobanking Science: Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy is one of the most common inherited heart diseases, affecting 1:200 people (1). Patients with hypertrophic cardiomyopathy have thickened left ventricles which can lead to life-threatening complications such as arrhythmias, heart failure and sudden death (2). Hypertrophic...
