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Some Brugada Syndrome Patients At Risk Of Sudden Cardiac Death Have GSTM3 Deletion

Brugada syndrome (BrS) is a disorder of the heart rhythm that can result in sudden cardiac death, which may be triggered by circumstances, and has a genetic basis. Faster, abnormal rhythm may be triggered by electrolyte imbalances, certain drugs,...

Age-Of-Onset Genome-Wide Association Studies In Allergic Disease

Susceptibility to allergic diseases can be predicted by genome-wide association studies (GWAS) based on biobanks of sequenced DNA from people with said diseases. Knowing the likely age-of-onset of these diseases would be helpful for risk management and lifestyle adjustment....

Lack Of African Biobank Data Results In Iron Deficiency Anaemia Remaining Unexplained

Iron is a dietary requirement, women aged 19-50 needing the most, routinely around 18mg/day, moreover all adults need at least 8mg/day. Pregnant women need even more. Dietary sources include, but are not limited to, meats, nuts, grains and broccoli....

Predicting Risk Of Fracture Using Polygenic Risk Score Of Speed Of Sound Through Bone

As we age, the risk of bone fracture increases. Doctors developed the Fracture Risk Assessment Tool (FRAX), which takes account of age, weight, gender, smoking history, alcohol use and family history of fracture, as an initial approach for managing...

Serum Uric Acid Predicts Kidney Cancer Incidence

According to the US Surveillance, Epidemiology, and End Results program, the outlook for kidney cancer patients is generally favourable with an overall five year survival rate of 77%, furthermore the survival rate in the 65-74 age category is still...

PALB2 May Be A Risk Locus For Ovarian Cancer

According to US Surveillance, Epidemiology, and End Results (SEER), overall, the five year survival rate for ovarian cancer is 49%, however for those aged 15-39 the survival rate is 81% and declines steadily with age; 65-74 year olds having...

Estrogen Receptor Isoforms Are Down-Regulated In Hepatocellular Carcinoma

Estrogen receptor alpha (ERα) translocates to the nucleus and induces gene expression upon activation. The estrogen receptor is a target of US Food and Drug Administration FDA approved drugs such as the selective estrogen receptor degrader called Fulvestrant, which...

Apolipoprotein E (APOE) Isoform Association With Aging In UK Biobank

The APOE (Apolipoprotein E) gene has three main isoforms known as APOE2, APOE3, and APOE4. The ε4 allele is thought to be the oldest, whereas ε2 is the most recently evolved. In the European ancestry population the frequency of...

Genetics Of Susceptibility To Viral Infection

The severity of infectious diseases vary from person to person partly due to individual genetic factors. This can shape genetics at the population level, for example inherited sickle cell disease can protect against malarial infection, and is therefore advantageous...

COVID-19 Risk In Different Ethnic And Socioeconomic Groups Within UK Biobank

Socioeconomic and ethnic factors may influence the risk of viral infection. For example, both economic circumstances and cultural influences may impact the extent to which people can implement distancing measures, thus modifying their risk. The extent to which this...

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