Syntegra Partners with Nashville Biosciences on Biobank Data Analysis for Drug R&D

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Syntegra and Nashville Biosciences, a wholly owned subsidiary of Vanderbilt University Medical Center (VUMC), just announced a collaboration to accelerate data driven innovation and research for drug discovery and development.

Nashville Biosciences was created to facilitate commercial R&D uses of VUMC’s comprehensive and growing BioVU® biorepository, a de-identified biobank of millions of longitudinal medical records spanning over 10 years with hundreds of thousands of linked genetic samples. Syntegra’s ability to create statistically accurate but non-identifiable synthetic populations from this data will create expanded opportunities for discovery, research and innovation through applications such as cohort expansion, missingness imputation and bias normalization, while adding a further layer of privacy protection for the underlying real-world data derived from VUMC’s electronic medical records. Syntegra and Nashville Biosciences will work together to lay the groundwork for these opportunities, initially validating the use of synthetic data to recreate a recent study done in collaboration between Nashville Biosciences and another collaborator comparing the performance of various treatments for type 2 diabetes.

Michael D. Lesh, SM MD FACC, founder and CEO of Syntegra commented, “We are excited to work with Nashville Biosciences to validate that synthetic data, generated by the Syntegra Medical Mind, provides the same clinical utility as real-world data, without the privacy risk.  Synthetic data will unlock opportunities to dramatically accelerate how life-saving treatments reach patients.”

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“The Syntegra Medical Mind works by extracting patterns of care within real data, and then creating a complete replica dataset,” added Ofer Mendelevitch, Syntegra cofounder and CTO. “These synthetic digital twins have the same statistical properties as the real data. However, there is no way to identify the information belonging to any real patient.”

Leeland Ekstrom, PhD, COO and cofounder of Nashville Biosciences said, “We are constantly looking for innovative new tools and approaches that we can deploy against our clients’ R&D problems. The Syntegra Medical Mind is an analytic approach that does exactly that, and we are excited to test it in this specific application.”