Perspectum Diagnostics Awarded Grant For Quantitative MRI Of Organs In Type 2 Diabetes Patients

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Perspectum Diagnostics has announced a successful Innovate UK grant award to develop technology that will improve the diagnosis and monitoring of type 2 diabetes (T2D).

Perspectum Diagnostics is an Oxford, UK based company founded in 2012, in partnership with the University of Oxford, that is dedicated to the creation of safe, non-invasive alternatives to traditional abdominal testing methods. Their vision is to empower patients and clinicians through greater understanding of disease, enabling early detection, diagnosis and targeted treatment.

Innovate UK’s grant will fund Perspectum to develop a stratification strategy for patients with T2D using a quantitative MRI assessment of organs, including the liver, kidneys, pancreas, spleen and the aorta. In order to tailor effective treatment, diagnosis must account for the presence or absence of multi-organ complications. Combining these biomarkers into a medical device will support clinical management based on a single, cost-effective MRI scan.

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Building on Perspectum’s existing in-house capabilities, this project will provide disease stratification, improve patient compliance, reduce NHS costs, and enable precision treatment. This multi-organ project was preceded by Perspectum’s MRI-based research using the UK Biobank, which highlighted the significant burden of unrecognised liver disease, such as NAFLD, which is three times more prevalent in T2D.

“This project has the potential to greatly enhance our understanding of organ dysfunction and T2D severity. Hopefully, this will enable us to improve patient stratification, which will accelerate diagnosis of diabetes-related complications and support the development of personalised treatments.” – Dr Gaya Thanablasingham, specialist in Endocrinology and Metabolic Medicine at Oxford University Hospitals NHS Foundation Trust

“T2D is dramatically increasing worldwide and can cause damage to multiple organs in time if not treated effectively. This innovative research study will allow us to visualise these organs early on in T2D, which will assist pathways to stratify treatment in the management of the disease.” – Sarah Ali, Consultant in Endocrinology, Diabetes and General Medicine at the Royal Free London NHS Foundation Trust

“Screening for liver and cardiovascular complications is still sub-optimal and this multi-organ assessment in diagnosis and treatment of T2D allows us to better understand the prevalence and progression of disease as well as the impact of different treatments. It hopefully will lead to better treatment stratification.” – Professor Dan Cuthbertson, a Consultant Diabeteologist at University Hospital Aintree, University of Liverpool