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Leptin Associated With Cognitive Impairment In Older Adults Scheduled For Surgery

Adipokines are cytokines secreted by adipose (fat) tissue. Their existence was first noted in 1994, with the discovery of leptin. This cytokine is known to suppress hunger, but also promotes atherosclerosis, endothelial dysfunction and inflammation. Another adipokine, adiponectin is...

Migraine Medication Overuse Prediction Using Machine Learning

The underlying mechanism of migraine headache is still poorly understood and is likely results due to a combination of genetics and “trigger” events. The patient population is therefore highly diverse and no one treatment fits all migraine sufferers. The...

Iron Loading Reduced Insulin Secretion By Pancreatic Beta-Cell Lines

Longitudinal analyses of iron-overloaded individuals have indicated that patients in the highest quartile of serum ferritin levels, a proxy for iron, have 3.5-fold greater risk of developing Type II Diabetes over a 6-year period. The exact mechanism is unclear...

Lack Of African Biobank Data Results In Iron Deficiency Anaemia Remaining Unexplained

Iron is a dietary requirement, women aged 19-50 needing the most, routinely around 18mg/day, moreover all adults need at least 8mg/day. Pregnant women need even more. Dietary sources include, but are not limited to, meats, nuts, grains and broccoli....

Predicting Risk Of Fracture Using Polygenic Risk Score Of Speed Of Sound Through Bone

As we age, the risk of bone fracture increases. Doctors developed the Fracture Risk Assessment Tool (FRAX), which takes account of age, weight, gender, smoking history, alcohol use and family history of fracture, as an initial approach for managing...

Multiplex Method For Detection Of Pathogenic Pig Coronaviruses

Pathogenic pig coronaviruses found in the intestine (enteric) produce similar symptoms, namely diarrhea with a reduced ability to digest food leading to dehydration and starvation. Transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine deltacoronavirus (PDCoV) are...

Lessons Learned From Participation In The 100,000 Genomes Project

The 100,000 Genomes Project (100KGP) was established to sequence genomes from people including around 85,000 UK National Health Service (NHS) patients affected by a rare disease, or cancer. Announced in 2012, the main aims were to: establish genomic medicine provision...

Learning From Human Bile – A Machine Intelligence Approach

The digestive fluid called bile is made up of acids, salts, fats, and the pigment bilirubin, stored and concentrated in the gall bladder, and produced by the liver. Protein is a significant component of bile, 5% of the dry...

An Organoid Model Of The Human Midbrain

In Parkinson’s disease dopaminergic neurons are irrecoverably lost from the midbrain resulting in slowed movement, tremors and other symptoms. Dopamine augmentation is the main treatment for Parkinson’s, however, there is no cure available that can reverse the symptoms, partly...

Collagen Content Changes Detected By Raman Spectroscopy In Herniated Spinal Chord

In the spinal cord, the nucleus pulposus (NP) is the collagen rich core of the intervertebral discs. Intervertebral disc degeneration (IDD) is thought to be a major contributor to lower back pain, which the majority of people will experience...

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