Latest Research

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Leptin Associated With Cognitive Impairment In Older Adults Scheduled For Surgery

Adipokines are cytokines secreted by adipose (fat) tissue. Their existence was first noted in 1994, with the discovery of leptin. This cytokine is known to suppress hunger, but also promotes atherosclerosis, endothelial dysfunction and inflammation. Another adipokine, adiponectin is...

A Ubiquitination Inhibitor Hakin-1 Potentially Has Efficacy In Colorectal Cancer

Hakai is a 491 amino acid E3 ubiquitin-protein ligase that forms a dimer if zinc is available. This allows Src tyrosine kinase dependant interaction with the transmembrane adhesion protein E-cadherin. This interaction results in ubiquitination and degradation of E-cadherin,...

Multiplex Method For Detection Of Pathogenic Pig Coronaviruses

Pathogenic pig coronaviruses found in the intestine (enteric) produce similar symptoms, namely diarrhea with a reduced ability to digest food leading to dehydration and starvation. Transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine deltacoronavirus (PDCoV) are...

Iron Loading Reduced Insulin Secretion By Pancreatic Beta-Cell Lines

Longitudinal analyses of iron-overloaded individuals have indicated that patients in the highest quartile of serum ferritin levels, a proxy for iron, have 3.5-fold greater risk of developing Type II Diabetes over a 6-year period. The exact mechanism is unclear...

WTAP Gene Polymorphisms Modify Risk Of Hepatoblastoma

Hepatoblastoma is a form of cancer that accounts for 80% of childhood liver cancers, but only 1% of childhood cancers in total. It usually presents between birth and three years of age. As it is a relatively rare tumour...

Establishing A Pediatric COVID-19 Biorepository

The global pandemic of COVID-19, caused by the highly infectious and transmissible coronavirus, SARS-CoV-2, has become a leading cause of death in older adults. The risk of severe disease and death has been highest in older patients and in...

Learning From Human Bile – A Machine Intelligence Approach

The digestive fluid called bile is made up of acids, salts, fats, and the pigment bilirubin, stored and concentrated in the gall bladder, and produced by the liver. Protein is a significant component of bile, 5% of the dry...

EU-CardioRNA COST Action Meetings Report Released

The European Cooperation in Science and Technology (COST Association) runs an EU-funded programme that encourages researchers and innovators to create research networks called COST Actions. The EU-CardioRNA COST Action, launched in 2018, is intended to promote transcriptomics research in...

Collagen Content Changes Detected By Raman Spectroscopy In Herniated Spinal Chord

In the spinal cord, the nucleus pulposus (NP) is the collagen rich core of the intervertebral discs. Intervertebral disc degeneration (IDD) is thought to be a major contributor to lower back pain, which the majority of people will experience...

Using Biobank Data to Estimate Genetic Variants Associated with Mortality in COVID-19 Patients

Coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1. The severity of COVID-19 and course of the infection is highly heterogenous. The majority of COVID-19 cases only have mild or...

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