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Colorectal Cancer: A Biobank of Patient-derived Xenografts

According to GLOBOCAN 2018 data, colorectal cancer (CRC) is the third most deadly and fourth most commonly diagnosed cancer in the world. There were nearly 2 million new cases and about 1 million deaths in 2018. The incidence of...

Thousands of Undiagnosed Cases of Type 2 Diabetes Identified by Screening UK Biobank Blood...

A study of approximately 200,000 blood samples from the UK Biobank has identified more than 2,000 undiagnosed cases of type 2 diabetes. The study, presented at this year's Annual Meeting of the European Association for the Study of Diabetes...

Infrastructure Needed for Biobanking the World’s Microbiomes

A team of scientists, led by CABI’s Dr Matthew Ryan, have outlined a series of challenges and opportunities presented in a necessary review of how microbiomes – biological communities including bacteria, archaea, fungi, algae, protists and viruses – can...

Water On The Brain: A Biobank Of Failed Shunt Devices

Hydrocephalus, otherwise known as water on the brain, is a condition where cerebrospinal fluid (CSF) accumulates within the brain. Hydrocephalus that occurs in childhood has a frequency of about 1 person in 1100 within the USA. The surgical placement...

Recapitulating Pharmacology With Genetics

The medical term for heart rate over 100 beats per minute is tachycardia. The small molecule ivabradine reduces heart rate via specific inhibition of the pacemaker current. It is also used to alleviate chest pain (angina pectoris) and as...

Cell Biobanks Are Critical For Organoids, Organ-On-Chips, And Additive Manufacturing

While the original 2D cell culture methods remain indispensable for routine laboratory operations and biochemical analyses it has become increasingly clear that they do not accurately represent organ systems in the body. To fully understand a system or device...

Biomarker Changes In Skin Keratinocytes Responsive To Blood Glucose

Biomarkers in the skin can reflect disease status in conditions as diverse as diabetes,  rheumatism, lung disease, and neurodegenerative diseases. In the case of diabetes, minimally invasive skin mounted glucose monitoring devices exist. Each device has its pros and...

Is The ACE Job–Exposure Matrix More Broadly Applicable In The UK Biobank?

A job-exposure matrix (JEM) is an approximation of potential health hazard exposures used in occupational epidemiological studies. The matrix of exposure levels to toxic or potentially harmful agents is extrapolated from occupational titles. As workplaces and individual circumstances vary...

A Prototype Sample Locator For The German Biobank Alliance

As of 2020, the German Biobank Alliance (GBA) consists of 20 biobanks distributed across the country. The GBA is coordinated by the German Biobank Node (GBN) organization. Researchers wishing to access biosamples within the GBA biobanks currently directly contact...

Design And Testing Of A Dendritic Cell Therapy Vaccine Against HIV-1

Infection with the human immunodeficiency virus 1 (HIV-1) is now a manageable condition, rather than a death sentence, as it once was. This is largely due to the development and commercialization of antiretroviral therapy (ART). In 2010 the annual...

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