Eliminating Helicobacter Pylori Reduced Risk Of Gastric Cancer By 75% In An American Population

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In a new study published in the journal Gastroenterology, researchers in the Perelman School of Medicine at the University of Pennsylvania have found, after analyzing records of close to 400,000 patients, that successfully eliminating Helicobacter pylori from one’s gastrointestinal tract led to a 75 percent reduction in risk of gastric cancer. They also found that rates of gastric cancer after detection of H. pylori infection are higher among specific populations, suggesting that people who fall into these groups could benefit from more careful monitoring. The study is timely as while a link between the bacteria H. pylori and rates of gastric cancer, commonly referred to as stomach cancer, is well known, the rates and risk among Americans has been largely understudied.

Penn Medicine’s history of patient care began more than two centuries ago with the founding of the USA’s first hospital, Pennsylvania Hospital, in 1751 and the nation’s first medical school at the University of Pennsylvania in 1765. The Perelman School of Medicine at the University of Pennsylvania consistently ranks among the top five in US News and World Report’s rankings of research-oriented medical schools. Penn Medicine’s mission is to advance knowledge and improve health through research, patient care, and the education of trainees in an inclusive culture that embraces diversity, fosters innovation, stimulates critical thinking, supports lifelong learning, and sustains their legacy of excellence.

H. pylori is estimated to infect half of the world’s population, largely those in the eastern parts of the world. It can cause ulcers and other gastrointestinal issues but does not cause issues in the majority of people, and so many people are unaware they have it.

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The research team found that African American, Asian, Hispanic and Latinx, American Indian and Inuit Americans have significantly higher risk of H. pylori infection and of developing gastric cancer. Risks, when compared to the general population, are also higher among men, those who smoke, and among those whose H. pylori infection is detected in older age.

The study’s lead author Shria Kumar, MD, and the research team also saw that eradication of H. pylori infection dropped gastric cancer risk by about 75 percent, but that simply prescribing the H. pylori regimen does not decrease the likelihood of getting this cancer. Authors noted that this finding suggests physicians should ensure that the bacteria is eradicated after treatment, a consensus guideline recommendation that is often not followed due to the cumbersome nature of H. pylori testing.

While H. pylori and gastric cancer have serious consequences, Kumar is optimistic that the information from this study can lead to further research on the merits of increasing screening. Screening for H. pylori requires an endoscopic procedure, breath test, or stool sample, so it’s necessarily not easy. In addition, even among the number of people in the United States who contract H. pylori, most do not develop gastric cancer.

“The problem was that all research out of the U.S. used to study gastric cancer and determine American’s risk of developing it did not take into account H. pylori infection, and studies worldwide have shown this infection is actually the leading risk factor for this type of cancer.”

“According to estimates, there will be 27,000 new cases of gastric cancer in the U.S. this year, which is small compared to the prevalence of colorectal cancer – for which there is an estimated 101,000 new cases for 2019.” … “It’s not feasible or necessary to screen everyone for H. pylori or gastric cancer, but our study suggests that certain people may have high enough compounding risk to warrant regular invasive screenings and anyone treated for an H. pylori infection should be assessed to ensure eradication of the bacteria.” – Shria Kumar, MD, lead author, fellow in the division of Gastroenterology, Perelman School of Medicine


  1. https://www.pennmedicine.org/news/news-releases/2019/november/eliminating-common-bacterial-infection-significantly-decreases-gastric-cancer-risk
  2. https://www.med.upenn.edu/psom/overview.html