Down Syndrome Research Biobank Launched via a Collaboration between Cincinnati Children’s and DownSyndrome Achieves

Storage of biospecimens in minus-80 degrees Celsius freezers helps to ensure their preservation and usefulness for many years. (Credit: Cincinnati Children's)
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Cincinnati Children’s Hospital Medical Center has collaborated with DownSyndrome Achieves (DSA) to launch a research biobank, which serves as a central repository for biospecimens donated by individuals with Down syndrome and their immediate families.

The DSA Biobank aims to improve clinical care and health outcomes for individuals with Down syndrome and others by housing high-quality, well-annotated biospecimens that aid in driving basic, translational, and clinical research.

The DSA Biobank team at Cincinnati Children’s includes:

Featured Partners
  • The laboratory of William Nichols, PhD, associate director of research in the Division of Human Genetics at Cincinnati Children’s
  • The Cincinnati Children’s Discover Together Biobank, which is directed by Michael Pauciulo, MBA.

The Discover Together Biobank at Cincinnati Children’s is a secure facility for a variety of blood, saliva, and tissue samples as well as related information that helps researchers drive scientific breakthroughs.

“The DSA Biobank will create an important, novel biospecimen resource for the Down syndrome research community. In leveraging our existing expertise in the collection, processing, and storing of biological specimens and clinical data over the course of the last decade in my laboratory, this new partnership with DownSyndrome Achieves and the Cincinnati Children’s Discover Together Biobank is the continued application and expansion of our biobanking efforts.”


Dr. William Nichols, associate director of research in the Division of Human Genetics at Cincinnati Children’s

“Incorporated into the DSA Biobank model are many of the Discover Together Biobank’s institutional concepts behind broad consent, sample governance, and wide sharing of biospecimens/data. This partnership with DSA and Dr. Nichols continues Discover Together down the path of utilizing our biobanking expertise and infrastructure to partner with national and regional research networks. We couldn’t be more excited to leverage our resources to help DSA improve health outcomes for the Down syndrome population.”


Michael Pauciulo, MBA, Director at the Cincinnati Children’s Discover Together Biobank

Institutional Review Board protocol has been approved, and a pilot phase of operations has been completed with enrollment from Lee Specialty Clinic in Louisville. Additional Down syndrome clinics are slated to start enrollment later this year, including at Cincinnati Children’s.

Lito Ramirez, CEO of DownSyndrome Achieves, described the new DSA Biobank as a national resource.

“DSA Biobank, in partnership with Cincinnati Children’s Hospital, provides researchers with the potential to unlock some of the mysteries associated with Down syndrome. Currently, researchers do not have readily available blood and other samples to advance our understanding of the conditions that co-occur with Down syndrome. I’m excited the Down syndrome community will have this national resource, which is long overdue.”


Lito Ramirez, CEO of DownSyndrome Achieves