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David Orchard-Webb, PhD

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David is a consultant/medical writer for a number of ongoing healthcare initiatives including for Athla LLC/ HealthLabs, a discovery automation company for Big Data leveraging Big Compute. He has a number of years experience in academic R&D and healthcare related projects including the fields of oncology and immunotherapy.

A Standardized Mega-Biobank Phenomic Library From The Million Veteran Program

Often International Classification of Diseases (ICD) codes are used as a proxy for clinical phenotypes, however their intended purpose is for billing, determining treatment, and statistics collection and therefore may not always be the best representation of...

Mapping Existing Biobank Data To EHR Common Data Model Not Clean Or Straightforward

The Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) information synthesis approach transforms data contained within electronic health records (EHR) and other medical databases into a common format with a common terminology, vocabulary, and coding scheme....

A New Severity Score For Fabry Disease

Fabry disease is caused by loss of function mutations in the X-linked GLA gene, which encodes the enzyme alpha-galactosidase (α-GAL). The main symptoms include localized and full body pain (nervous system), which increases over time, kidney disease,...

EU-CardioRNA COST Action Meetings Report Released

The European Cooperation in Science and Technology (COST Association) runs an EU-funded programme that encourages researchers and innovators to create research networks called COST Actions. The EU-CardioRNA COST Action, launched in 2018, is intended to promote transcriptomics...

A Ubiquitination Inhibitor Hakin-1 Potentially Has Efficacy In Colorectal Cancer

Hakai is a 491 amino acid E3 ubiquitin-protein ligase that forms a dimer if zinc is available. This allows Src tyrosine kinase dependant interaction with the transmembrane adhesion protein E-cadherin. This interaction results in ubiquitination and degradation...

Proteomic Study Of Alzheimer’s With ApoE4

Apolipoprotein E (APOE) is a 299 amino acid protein which can be induced by consuming foods rich in cholesterol. The APOE gene has three main alleles termed ε2-4, which are translated into the proteins ApoE2-4. Apolipoproteins play...

Vitamin D Status Did Not Predict COVID-19 Infection Risk In The UK Biobank

A recent meta-analysis of 25 clinical trials located in 15 countries conducted by the UK National Health Service (NHS), Institute for Health Research, indicated that vitamin D supplements reduced the risk of acute respiratory infection (ARI) from...

How Do People In Nashville React To The Biobank Consent Process?

Gathering informed consent from participants is a pillar of biobanking. As ambitious biobanking projects such as All of US and UK biobank proliferate and become ever larger, the benefits and the potential risks for participants also grow....

Therapeutic Avenue For Acute Coronary Syndrome? – Exploring The Circular RNA Profile

Circular RNAs (circRNA) result from pre-mRNA back-splicing. Next generation sequencing has a blind spot for these circRNAs due to their lack of polyA tails and thus their abundance has only recently been appreciated. Using appropriate primers and/or...

Microbial Communities Associated With Cystic Fibrosis

Much of the morbidity and mortality of cystic fibrosis (CF), an inherited mucus condition of the lungs, is due to infections by the bacterial pathogen Pseudomonas aeruginosa. Some data indicate that between 60-80% of CF patients are...

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