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David Orchard-Webb, PhD

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David is a consultant/medical writer for a number of ongoing healthcare initiatives including for Athla LLC/ HealthLabs, a discovery automation company for Big Data leveraging Big Compute. He has a number of years experience in academic R&D and healthcare related projects including the fields of oncology and immunotherapy.

The Shanghai Suburban Adult Cohort And Biobank

The population of China is estimated to be 1.41 billion people, at least 16.87 million of whom live in the Shanghai metropolitan area. The urban landscape has undergone rapid development. In 1990 the percentage of the Chinese...

Some Brugada Syndrome Patients At Risk Of Sudden Cardiac Death Have GSTM3 Deletion

Brugada syndrome (BrS) is a disorder of the heart rhythm that can result in sudden cardiac death, which may be triggered by circumstances, and has a genetic basis. Faster, abnormal rhythm may be triggered by electrolyte imbalances,...

Iron Loading Reduced Insulin Secretion By Pancreatic Beta-Cell Lines

Longitudinal analyses of iron-overloaded individuals have indicated that patients in the highest quartile of serum ferritin levels, a proxy for iron, have 3.5-fold greater risk of developing Type II Diabetes over a 6-year period. The exact mechanism...

Age-Of-Onset Genome-Wide Association Studies In Allergic Disease

Susceptibility to allergic diseases can be predicted by genome-wide association studies (GWAS) based on biobanks of sequenced DNA from people with said diseases. Knowing the likely age-of-onset of these diseases would be helpful for risk management and...

Lack Of African Biobank Data Results In Iron Deficiency Anaemia Remaining Unexplained

Iron is a dietary requirement, women aged 19-50 needing the most, routinely around 18mg/day, moreover all adults need at least 8mg/day. Pregnant women need even more. Dietary sources include, but are not limited to, meats, nuts, grains...

Predicting Risk Of Fracture Using Polygenic Risk Score Of Speed Of Sound Through Bone

As we age, the risk of bone fracture increases. Doctors developed the Fracture Risk Assessment Tool (FRAX), which takes account of age, weight, gender, smoking history, alcohol use and family history of fracture, as an initial approach...

Biomarker Candidates For Dementia With Lewy Bodies Identified In Cerebrospinal Fluid

Besides Alzheimer’s disease (AD), Dementia with Lewy Bodies (DLB) is the second most common form of progressive dementia, accounting for up to 20% of cases. The main protein component of Lewy Bodies, which form in the nerve...

Multiplex Method For Detection Of Pathogenic Pig Coronaviruses

Pathogenic pig coronaviruses found in the intestine (enteric) produce similar symptoms, namely diarrhea with a reduced ability to digest food leading to dehydration and starvation. Transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine deltacoronavirus...

Lessons Learned From Participation In The 100,000 Genomes Project

The 100,000 Genomes Project (100KGP) was established to sequence genomes from people including around 85,000 UK National Health Service (NHS) patients affected by a rare disease, or cancer. Announced in 2012, the main aims were to:

Learning From Human Bile – A Machine Intelligence Approach

The digestive fluid called bile is made up of acids, salts, fats, and the pigment bilirubin, stored and concentrated in the gall bladder, and produced by the liver. Protein is a significant component of bile, 5% of...

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